Michele FIORE


Dr Michele FIORE (MCF)

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04 72 44 80 80

2019 - Present : Associate Professor (MCF HDR), Université Claude Bernard Lyon 1
: Habilitation à Diriger les Recherches (HDR), Université Claude Bernard Lyon 1
2014 - 2019
: Assistant Professor (MCF), Université Claude Bernard Lyon 1
2011 - 2014 : Postdoctoral studies, Université Grenoble Alpes (Prof Olivier Renaudet)
2009 - 2011 : Junior Scientist, Sienabiotech Spa (Italy)
2008 - 2009 : Postdoctoral studies, University of Ferrara (Prof Alessandro Dondoni / Prof Alberto Marra)
2003 - 2007 : PhD in Agrobiology and Agrochemistry, University of Naples (Prof. Antonio Evidente)


Editorial contribution:


Guest Editor for the Special Issue of LIFE (ISSN 2075-1729) in the series Origin of Life:
Special Issue "The Origin and Early Evolution of Life: Prebiotic Systems Chemistry Perspective"

Editor of the Book : Prebiotic Chemistry and Origin of Life Royal Chemical Society



44. Chromatophores Efficiently Promote Light-Driven ATP Synthesis and DNA 3 Transcription Inside Hybrid Multi-Compartment Artificial Cells.

E. Altamura, P. Albanese, R. Marotta, F. Milano, M. Fiore, M. Trotta, P. Stano and F. Mavelli

bioRxiv, doi: https://doi.org/10.1101/2020.02.05.933846


43. Chemical Analysis of Lipid Boundaries after Consecutive Growth and Division of Supported Giant Vesicles

A. Lopez, D. Fayolle, M. Fiore*, P. Strazewski

iScience, 2020, 23, 101677; https://doi.org/10.1016/j.isci.2020.101677


42. How lipids symmetry breaking occurred in common cell ancestors?

M. Fiore,* R. Buchet,

Symmetry 2020, 12, 1488; doi:10.3390/sym12091488


41. Racemic phospholipids for origin of life studies

E. Altamura, A. Comte, A. D’Onofrio, C. Roussillon, D. Fayolle, R. Buchet, F. Mavelli, P. Stano, M. Fiore,* P. Strazewski

Symmetry 2020, 12, 1108; doi:10.3390/sym12071108


40. The Origin and Early Evolution of Life: Prebiotic Chemistry.

M. Fiore

Life, 2019, 9, 73; doi:10.3390/life9030073


39. Investigating prebiotic protocells for a comprehensive understanding of the origins of life: a prebiotic systems chemistry perspective.

A. Lopez & M. Fiore*

Life, 2019, 9, 49; doi:10.3390/life9020049


37. Towards the preparation of synthetic outer membrane vesicle models with micromolar affinity to wheat germ agglutinin using a dialkyl thioglycoside.

D. Fayolle, B. Doumèche, N. Berthet, O. Renaudet, P. Strazewski and M. Fiore*

Beilstein J. Org. Chem. 2019, 15, 937–946. doi:10.3762/bjoc.15.90


36. Identification of a new natural gastric lipase inhibitor from star anise

J. Kamoun, R. Rahiern, M. Sellami, I. Koubaa, P. Mansuelle, R. Lebrun, A. Berlioz-Barbier, M. Fiore, K. Alvarez, A. Abousalham, F. Carrière, A. Aloulou,

Food Funct, 2019, 10, 469-478


35. The synthesis of mono-alkyl phosphates and their derivatives: an overview of their nature, preparation and use, including synthesis under plausible prebiotic conditions.

M. Fiore*,

Org. Biomol. Chem., 2018, 16, 3068–3086


34. Rapid purification of giant lipid vesicles by microfiltration.

D. Fayolle, M. Fiore, P. Stano and P.Strazewski;

PLoS ONE, 2018, 13: e0192975, DOI:10.1371/journal.pone.0192975


33. Glass Microsphere-Supported Giant Vesicles as Tools for Observation of Self-reproduction of Lipid Boundaries;

M. Fiore*, O. Maniti, A. Girard-Egrot, P-A Monnard and P. Strazewski*

Angew. Chem. Int. Ed., 2018, 57, 282–286;


32. Multivalent Glycomimetics with Affinity and Selectivity toward Fucose-Binding Receptors from Emerging Pathogens

D. Goyard, V. Baldoneschi, A. Varrot, M. Fiore, A. Imberty, B. Richichi, O. Renaudet, and C. Nativi

Bioconjugate Chem. 2018, 29, 83−88


31. Crude phosphorylation mixtures containing racemic lipid amphiphiles self-assemble to give stable primitive compartments; D. Fayolle, E. Altamura, A. D’Onofrio, W. J. Madanamothoo, B. Fenet, F. Mavelli, R. Buchet, P. Stano*, M. Fiore* and P.Strazewski*

Sci. Rep., 2017, 7, 18106;


30. Giant vesicles from rehydrated crude phosphorylation mixtures containing mono-alkyl phosphoethanolamine and its analogues;

M. Fiore*, W. Madanamoothoo, A. Berlioz-Barbier, O. Manniti, A. Girard-Egrot, R. Buchet, P. Strazewski*;

Org. Biomol. Chem., 2017, 15, 4231–4238.


29. Bringing down to earth prebiotic nucleosides and nucleotides 

M. Fiore, P. Strazewski*;

Angew. Chem. Int. Ed., 2016, 55, 13930–13933.


28. Prebiotic lipidic amphiphiles and condensing agents on the early Earth

M. Fiore*, P. Strazewski*

Life, 2016, 6, 17.


27. Immunological characterization of a rigid α-Tn mimetic on murine iNKT and human NK cells.

S. Fallarini, A. Brittoli, M. Fiore, G. Lombardi, O. Renaudet, B. Richichi, C. Nativi,

Glycoconj. J., 2017, 34, 553–562.


26. Chemo-bacterial synthesis of a sialyl-Tn cyclopeptide vaccine Candidate.

E. Richard, C. Pifferi, M. Fiore, E. Samain, A. Le Gouëllec, S. Fort, O. Renaudet, B. Priem,

ChemBioChem., 2017,18, 1730–1734.


25. Aminooxiylated Carbohydrates: Synthesis and Applications.

C. Pifferi, G. C. Daskhan, M. Fiore, T. C. Shiao, R. Roy, O. Renaudet,

Chem. Rev. 2017, 117, 9839−9873.


24. Role of a preorganized scaffold presenting four residues of a GM3 lactone mimetic on melanoma progression

B. Richichi, G. Comito, O. Renaudet, M. Fiore, A. Marra, B. Stecca, L. Pasquato, P. Chiarugi, C. Nativi

ACS Med. Chem. Lett., 2016, 7, 28–33.


23. Divergent and convergent synthesis of GalNAc-conjugated dendrimers using dual orthogonal ligations

B. Thomas, C. Pifferi, G. C. Daskhan,M. Fiore, N. Berthet, O. Renaudet

Org. Biomol. Chem., 2015, 13, 11529–11538.


22. Multivalent glycocyclopeptides: toward nano-sized glycostructures

G. C. Daskhan, N. Berthet, B. Thomas, M. Fiore, O. Renaudet

Carbohyd. Res., 2015, 405, 13–22.


21. Oligomers for molecular recognition made by AROP of disubstituted cyclopropane-1,1-dicarboxiylates

S. Peyrat, M. Fiore, N. Illy, S. Boileau, V. Wintgens, N. Berthet, O. Renaudet, J. Penelle, V. Barbier, 

Proceeding MACRO 2014: Recent development in polymer synthesis, 284–286.


20. Clustered Tn-Antigen Mimetics-Based Cancer Therapeutic Vaccine Induces Strong Antibody-Mediated Protective Immunity

B. Richichi, B. Thomas, M. Fiore, R. Bosco, K. Kabbara, K. Cao, H. Qureshi, C. Nativi, O. Renaudet, L. Ben Mohamed,  Angew. Chem. Int. Ed., 2014, 53, 11917–11920.


19. A multi-ligation strategy for the synthesis of heterofunctionalized glycosylated scaffolds

B. Thomas, M. Fiore, G. C. Daskhan, N. Spinelli, O. Renaudet

Chem. Commun., 2014, 50, 8989–8992.


18. New glycopolimers as multivalent system for lectin recognition

M. Fiore, N. Berthet, O. Renaudet, V. Barbier

MedChem Comm., 2014, 5, 1202–1207.


17. Orthogonal dual thiol-chloroacetyl and thiol-ene couplings for the sequential one-pot assembly of heteroglycoclusters

M.Fiore, G. C.Daskhan, B. Thomas, O. Renaudet

Beilstein J. Org. Chem., 2014, 10, 1557–1563.


16. Access to topological biomolecular platform using a simple protocol based on oxiime ligation

K. Křenek, R. Gazak, M. Sulc, G. C. Daskhan, J. Garcia, M. Fiore, P. Dumy, V. Křen, O. Renaudet

Carbohyd. Res., 2014, 393, 9–14.


15. Reevaluation of binding properties of recombinant lymphocyte receptors NKR-P1A and CD69 to chemically synthesized glycans and peptides.

D. Rozbeský, J. Krejzová, K. Křenek, J. Prchal, R. Hrabal, M. Kozísek, L. Weignerová, M. Fiore, P. Dumy, O. Renaudet, V. Křen

Int. J. Mol. Sci., 2014, 14, 1271–1283.


14. Tetravalent GlcNAc Glycoclusters: influence of the Linker for the Weat Germ Agglutinin Interaction.

M. Fiore, N. Berthet, P. Dumy, A. Marra, A. Dondoni, E. Gillion, A. Imberty, O. Renaudet

Org. Biomol. Chem., 2013, 11, 7113–7122.


13. Facile Synthesis of multi-antigenic platform as vaccine candidates against cancers                 

M. Fiore, B. Thomas, V. Dulery, P. Dumy, O. Renaudet

New. J. Chem., 2013, 37, 286–289.  


12. Synthesis of heteroglycoclusters by using orthogonal chemoselective ligations

B. Thomas, M. Fiore, I. Bossu, P. Dumy, O. Renaudet

BeilsteinJ. Org. Chem., 2012, 8, 421–427.


11. Synthesis of S-glycosyl amino acids and S-glycosilpeptides via photoinduced click thiol-ene coupling

M. Fiore, S. Pacifico, M. Lo Conte, A. Marra, A. Dondoni

Tetrahedron Lett., 2011,  52 , 444–447.


10. Photoinduced Thiol Ene Coupling as a Click Ligation tool for Thiodisaccarides Synthesis

M. Fiore, A. Marra, A. Dondoni

J. Org. Chem., 2009, 74, 4422–4425.


09. Single and Dual glycoside clustering around calix[4]arene scaffolds via click thiol ene and azide-alkyne cycloaddition

M. Fiore, A. Chambery, A. Marra, A. Dondoni

Org. Biomol. Chem., 2009, 7, 3910–3913.


08. Effects of the aglycone of ascaulitoxin on amino acid metabolism in Lemna paucicostata

Stephen O. Duke, Antonio Evidente, Michele Fiore, Agnes M. Rimando, Franck E. Dayan, Maurizio Vurro, Nicole Christiansen, Ralf Looser, Johannes Hutzler, Klaus Grossmann

Pest. Biochem. Physiol., 2011, 100, 41–50.


07. Analysis of phytotoxiic fungal toxins from Ascochytacaulina liquid culture

Agnes M, Rimando, MicheleFiore, Antonio Evidente

Abstr. Pap. Am. Chem. S., 2010, 239, 96–99.


06. A new GC-MS method for the analysis of ascaulitoxin, its aglycone and 4-aminoproline from culture filtrates of Ascochitacaulina

Michele Fiore, Agnes Rimando, Anna Andolfi, Antonio Evidente

Anal. Methods, 2010, 2, 159–163.


05. Diplofuranones A and B, two Further New 4-Monosubstituted 2(3H)-dihydrofuranones Produced by Diplodiacorticola, a Fungus Pathogen of Cork Oak

Antonio Evidente, Anna Andolfi, Michele Fiore, Emanuela Spanu, Antonio Franceschini, Lucia Maddau Archiv. O. C., 2007, 7, 318–320.


04. Diplobifuranylones A and B, 5’-Monosubstituted Tetrahydro-2H-bifuranyl-5-ones Produced by Diplodiacorticola, a Fungus Pathogen of Cork Oak

Antonio Evidente, Anna Andolfi, Michele Fiore, Emanuela Spanu, Lucia Maddau, Antonio Franceschini, Francesco Marras, Andrea Motta

J. Nat. Prod., 2006, 69, 671–674.


03. Chemical and biological characterisation of sapinopyridione, a phytotoxic 3,3,6-trisubstituted-2,4-pyridione produced by Sphaeropsis sapinea, a toxigenic pathogen of native and exotic conifers, and its derivatives

Antonio Evidente, Michele Fiore, Giovanni Bruno,Lorenzo Sparapano, Andrea Motta

Phytochemistry, 2006, 67, 1019–1028.


02. Occurence, isolation and biological activity of phytotoxic metabolites produced in vitro by Spaeropsissapinea, pathogenic fungus of Pinusradiata

Annalisa Cabras, Maria A. Mannoni, Salvatorica Serra, Anna Andolfi, Michele Fiore, Antonio Evidente

Eur. J. Plant Path., 2006, 115, 187–193.


01. Stimulation of Orobancheramosa seed germination by fusicoccin derivatives: A structure–activity relationship study

Antonio Evidente, Anna Andolfi, Michele Fiore, Angela Boari, Maurizio Vurro

Phytochemistry, 2006, 67, 19–26.


Book editor


The Origin and Early Evolution of Life: Prebiotic Chemistry (2019)

M. Fiore, Editor. MDPI, St. Alban-Anlage 66

4052 Basel, Switzerland

ISBN 978-3-03921-606-2 (Pbk); ISBN 978-3-03921-607-9 (PDF)


Book chapters


Following the Growth and Division of Lipid Boundaries by Using

Glass Microsphere-Supported Protocells (2020)

A. Lopez, C. Chieffo, M. Fiore*

In: Book Series: Lecture Notes in Bioengineering

S. Piotto, S. Concilio, L. Sessa, F. Rossi, Editors

Publisher: Springer International Publishing

Print ISBN: 978-3-030-47704-2


Protecting groups for the primary position of carbohydrates (2018)

M. Donnier-Marechal, S. Vidal, M. Fiore*

In “Protecting Groups - Strategies and Applications in Carbohydrate Chemistry”

Wiley-VCH, Editor S. Vidal, Université de Lyon, Claude Bernard Lyon 1,

ISBN: 978-3-527-34010-1


Vaccines against cancer (2014)

M. Fiore, B. Thomas, G.C. Daskhan, O. Renaudet,

In Carbohydrates Chemistry: State-of-the-art and challenges for drug development

Imperial College Press, London, Editor Prof. L. Cipolla University of Milan, Italy

ISBN: 9781783267194


Chemical synthesis of carbohydrate-based vaccines against cancer (2013)

M. Fiore, B. Thomas, P. Dumy, O. Renaudet

In Biomaterials for cancer therapeutics, Woodhead Publishing (2013)

DOI : 10.1533/ 9780857098924.2.57; ISBN: 9780857096647